�Researchers hold discovered a central molecular switch in fruit fly embryos that opens young avenues for studying the causes of birth defects and genus Cancer in mankind. Writing about their subject in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a principal tuning mechanism for instructing cells whether to form sensory nervousness or line of descent cells in different parts of the body.
The molecular shift occurs when two central control genes, Hox and Senseless (Sens), compete for influence to regulate genetical signals that instruct cells to differentiate and begin tissue and/or blood formation, said Brian Gebelein, Ph.D., a research worker in the division of Developmental Biology at Cincinnati Children's and corresponding generator of the study.
Conserved between species through the course of evolution - all the way from Drosophilia fruit flies to vertebrates and humans - Hox genes are responsible for for regulation other downstream genes, to determine body position and help form major body structures during early development. Sens regulates downstream genes that support the development of sensory organs, such as those important to hearing, touch or sight.
Dr. Gebelein said the competition between Hox and Sens appears to be complementary, creating a balance of instructional influence that results in normal development. Looking onward the researchers plan to deepen their understanding of how this balance works, and what happens in the mode of birth defects or disease when it becomes unbalanced should Sens or Hox example excessive laterality.
"We at once have a central mechanics we can use as a peter to look for triggers in the genome that work with Hox and Sens to regulate the formation of neurons and blood cells," said Dr. Gebelein. "This allows us to identify other key genes downstream of Hox and Sens, determine their role in development based on what happens with cell destiny decisions, and look for the causes of birth defects and disease."
Although Hox genes have long been known to set apart distinct cellular telephone types along the development body axes of vertebrates and non-vertebrates, it hasn't been clear how they regulate downstream gene transcription to form specific cells or tissues. In what the researchers called "an unexpected Hox transcriptional mechanism," they detected the permissive regulation of a secreted protein called EGF, or epidermal growth factor. EGF is a cell courier protein that affects cell differentiation, maturation and epidermic development. The research team noticed that Hox's permissive regulation of EGF light-emitting diode to cellphone specification when it interacted with the influence of Sens in the peripheral nervous organization.
Dr. Gebelein's laboratory studies nervous system development and genes that specify nerve cell subtypes, their formation and how they migrate to their reserve locations in the development body. Understanding the influence of Hox transcription factors in cellular phone differentiation along the anterior and back tooth axis of the Drosophilia melangaster fruit fly is an authoritative focal point of this research.
In collaboration with H. Leighton Grimes, Ph.D., of Cincinnati Children's division of Immunobiology, Dr. Gebelein is too studying how Hox competes with Sens and its control of a growth factor called Gfi-1. In the current study, the researchers note that ongoing mouse studies at Cincinnati Children's express Gfi-1 and Hox are linked to neural and blood development. The researchers are looking at into the implications this has for leukemia, aforementioned Dr. Gebelein, also an associate prof of pediatric medicine at the University of Cincinnati School of Medicine.
Other researchers participating in the bailiwick included lead author, David Li-Kroeger, Lorraine M. Witt, Dr. Grimes and Tiffany A. Cook, all of Cincinnati Children's. Funding support came from an MOD Basil O'Connor Award, an ACS Ohio Pilot Grant, a grant from the Barrett Cancer Center at the University of Cincinnati and the National Institutes of Health.
Cincinnati Children's Hospital Medical Center is one of America's top three children's hospitals for general pediatrics and is highly ranked for its expertise in digestive diseases, respiratory diseases, cancer, neonatal care, warmheartedness care and neurosurgery, according to the annual ranking of best children's hospitals by U.S. News & World Report. One of the three largest children's hospitals in the U.S., Cincinnati Children's is attached with the University of Cincinnati College of Medicine and is one of the peak two recipients of pediatric research grants from the National Institutes of Health. For its achievements in transforming health care, Cincinnati Children's is one of sixer U.S. hospitals since 2002 to be awarded the American Hospital Association-McKesson Quest for Quality Prize � for leadership and foundation in timbre, safety and commitment to patient aid. The hospital is a national and international referral center for complex cases, so that children with the most difficult-to-treat diseases and weather condition receive the most sophisticated care leading to better outcomes. Additional information tin be constitute at hTTP://www.cincinnatichildrens.org.
Cincinnati Children's Hospital Medical Center
More info
Monday, 18 August 2008
Friday, 8 August 2008
Seventh Avenue
Artist: Seventh Avenue
Genre(s):
Rock
Metal: Power
Discography:
Goodbye
Year: 1999
Tracks: 7
Southgate
Year: 1998
Tracks: 12
Tales Of Tales
Year: 1996
Tracks: 11
Rainbowland
Year: 1995
Tracks: 14
Tuesday, 1 July 2008
DJ Guy Salama Feat Dynamic
Artist: DJ Guy Salama Feat Dynamic
Genre(s):
Other
Discography:
B-Trance On Radio Bu 99Fm 02-08-03
Year: 2003
Tracks: 1
Monday, 23 June 2008
Aznar Lebon
Artist: Aznar Lebon
Genre(s):
Other
Discography:
Aznar Lebon - Vol. 2
Year: 2007
Tracks: 12
Aznar Lebon - Vol. 1
Year: 2007
Tracks: 12
Voight to play villain on Fox's '24' next season
Monday, 16 June 2008
Jesse Malin
Artist: Jesse Malin
Genre(s):
Pop
Rock
Discography:
Glitter in the Gutter
Year: 2007
Tracks: 13
The Heat
Year: 2004
Tracks: 14
The Fine Art of Self Destruction
Year: 2003
Tracks: 12
Singer/songwriter Jesse Malin was the fount of the glam/hard careen ring D Generation for eight age, following the dissolving of Heart Attack, the hardcore punk act he fronted as a adolescent in the '80s. They weren't a metal banding, only critics cursorily laid-off D Generation as Johnny Thunders copycats. Their titillated hairsbreadth and calendered wardrobe were only a part of the act, merely substance and song dynasty structure were on that point. As one of New York City's more gifted acts of the nineties, the band released ternion albums ahead disbanding in April 1999. Malin, who's a tinder with a soft heart, didn't stay writing music. His lovemaking for Neil Young, Tom Waits, and Steve Earle affected his do work; he spent the succeeding iI days working on a fresh, rustic sound. Ex-Whiskeytown frontman Ryan Adams, who'd been a friend of Malin since the D Generation years, was impressed with Malin's new approaching. Adams offered to bring forth Malin's debut album even though he'd never produced a record. The two headed into Lo-Ho Studios in New York in January 2001 and made an album in only six-spot days. A carry on with Artemis shortly followed. The Fine Art of Self Destruction appeared in the U.K. in October 2002; first undivided "Queen of the Underworld" was a moderate hit and the British press quickly hailed Malin's debut as unrivaled of the year's best. Stateside fans lastly got their men on The Fine Art of Self Destruction in January 2003. Road dates followed, both in America and the U.K. Malin contributed a version of "Hungry Heart" to the benefit album Light of Day: A Tribute to Bruce Springsteen; he too picked up a nomination for the Shortlist Music Prize. By November he was back in the studio, egg laying depressed tracks for Self Destruction's followup. The Heat appeared in June 2004, attended by a string of circuit dates on both sides of the pond. Malin's third album was recorded in Los Angeles during the summer/fall of 2006, which marked his number one time making a book outside of New York (or even higher up 14th Street) during his life history. Featuring client muscae volitantes by Bruce Springsteen and Jakob Dylan, among others, Sparkle in the Gutter eventually surfaced in March 2007 via Billie Joe Armstrong's label Adeline Records. Malin worn-out most the year on the road with his championship band the Heat.
The Fratellis to release album 'a day early'
Friday, 6 June 2008
Chocolate Industries and Artist To Market Distribution (A2M) Announce Exclusive Distribution Agreement for The Cool Kids Debut Release, The Bake Sale
TROY, Mich., May 12 -- Artist To Market Distribution(A2M)
today announced it has entered into an agreement with Chicago based label,
Chocolate Industries, to be the exclusive distributor of the label's
highly-anticipated debut release from The Cool Kids, The Bake Sale. The
Bake Sale will be released on June 10th, 2008, and will carry a suggested
retail price of $9.98.
As with prior agreements, A2M provides artists, labels, and content
owners of all kinds with a streamlined and flexible supply chain solution
to both traditional and non-traditional music retail outlets, thus
bypassing the traditional music label infrastructure. This allows the album
to be offered at an attractive price to consumers, while enabling retailers
to achieve a fair profit margin.
Seven Bedard, Creative Director of Chocolate Industries, stated,
"Working with A2M will open new doors and possibilities for The Cool Kids
and Chocolate Industries, and we are looking forward to working with this
innovative company."
Paul Ignasinski, General Manager of A2M, commented, "We're beyond
excited to be partnering with The Cool Kids, Seven, and the entire
Chocolate Industries staff. It's great to be involved not only with this
incredible project, but also with a group of people motivated and genuinely
excited to approach the business in a fundamentally new way. In a business
so full of pessimism and sky-is-falling attitudes, these guys are
invigorating and we at A2M hope this is just the start of a long and
fruitful relationship."
The Cool Kids are in the midst of a sold-out world tour, including
stints with M.I.A., the upcoming Rock the Bells tour, and high-profile
festival performances such as Coachella 2008, Lollapalooza 2008, and
South-By-Southwest (SXSW) 2008. Check out http://www.myspace.com/gocoolkids for
more information and updates.
About Artist To Market Distribution
Launched in 2005, Artist To Market Distribution (A2M),
http://www.artist2market.com , is an independent distributor designed to work
directly with artists, labels, and content owners to streamline the supply
chain, and deliver new product to the marketplace at a lower cost. Over the
past two years A2M Distribution has partnered with a diverse group of
platinum and multi-platinum artists including Dolly Parton, Tracy Lawrence,
Tommy Lee, John Michael Montgomery, Sinead O'Connor, Unwritten Law, and
Tracy Byrd.
About Chocolate Industries
Established in 2000, Chocolate Industries is a forward-thinking record
label with an eclectic roster of artists. Based in Chicago, Chocolate
Industries is home to successful acts Lady Sovereign, Diverse, The Cool
Kids, Money Mark, and Free Moral Agents, and is distributed worldwide. The
label is built upon the idea that music and art not only coexist, but can
also have an involved relationship that extends beyond album cover art.
Nationally recognized graffiti and graphic artist, Cody Hudson, is the
Visual Art Director of Chocolate Industries.
See Also
today announced it has entered into an agreement with Chicago based label,
Chocolate Industries, to be the exclusive distributor of the label's
highly-anticipated debut release from The Cool Kids, The Bake Sale. The
Bake Sale will be released on June 10th, 2008, and will carry a suggested
retail price of $9.98.
As with prior agreements, A2M provides artists, labels, and content
owners of all kinds with a streamlined and flexible supply chain solution
to both traditional and non-traditional music retail outlets, thus
bypassing the traditional music label infrastructure. This allows the album
to be offered at an attractive price to consumers, while enabling retailers
to achieve a fair profit margin.
Seven Bedard, Creative Director of Chocolate Industries, stated,
"Working with A2M will open new doors and possibilities for The Cool Kids
and Chocolate Industries, and we are looking forward to working with this
innovative company."
Paul Ignasinski, General Manager of A2M, commented, "We're beyond
excited to be partnering with The Cool Kids, Seven, and the entire
Chocolate Industries staff. It's great to be involved not only with this
incredible project, but also with a group of people motivated and genuinely
excited to approach the business in a fundamentally new way. In a business
so full of pessimism and sky-is-falling attitudes, these guys are
invigorating and we at A2M hope this is just the start of a long and
fruitful relationship."
The Cool Kids are in the midst of a sold-out world tour, including
stints with M.I.A., the upcoming Rock the Bells tour, and high-profile
festival performances such as Coachella 2008, Lollapalooza 2008, and
South-By-Southwest (SXSW) 2008. Check out http://www.myspace.com/gocoolkids for
more information and updates.
About Artist To Market Distribution
Launched in 2005, Artist To Market Distribution (A2M),
http://www.artist2market.com , is an independent distributor designed to work
directly with artists, labels, and content owners to streamline the supply
chain, and deliver new product to the marketplace at a lower cost. Over the
past two years A2M Distribution has partnered with a diverse group of
platinum and multi-platinum artists including Dolly Parton, Tracy Lawrence,
Tommy Lee, John Michael Montgomery, Sinead O'Connor, Unwritten Law, and
Tracy Byrd.
About Chocolate Industries
Established in 2000, Chocolate Industries is a forward-thinking record
label with an eclectic roster of artists. Based in Chicago, Chocolate
Industries is home to successful acts Lady Sovereign, Diverse, The Cool
Kids, Money Mark, and Free Moral Agents, and is distributed worldwide. The
label is built upon the idea that music and art not only coexist, but can
also have an involved relationship that extends beyond album cover art.
Nationally recognized graffiti and graphic artist, Cody Hudson, is the
Visual Art Director of Chocolate Industries.
See Also
Tuesday, 27 May 2008
Secretary Denies Breaking Up Shania's Marriage
The alleged other woman is finally talking.
Marie-Anne Thi�baud, 37, the longtime secretary and house manager at Shania Twain and Mutt Lange's estate in Switzerland, spoke to E!...
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